Inception Sciences is growing. Join an innovative team of drug-discovery scientists dedicated to the development of high-value therapies for the treatment of serious human diseases.


Research Associate or equivalent level in San Diego

Inception Sciences in San Diego is looking for an enthusiastic, hard-working and highly-motivated applicant to join our world class research team developing small molecule therapeutics to treat Cancer, and Auto-Immune Diseases. The candidate should have experience in rodent handling, dosing and tissue collection that are needed to support in vivo pharmacokinetic, pharmacodynamic and small molecule drug efficacy studies. Experience related to in vivo models of cancer and/or immunity is required. Additional expertise in laboratory techniques such as sterile tissue culture, developing and maintaining cell lines and in biochemical techniques including, Western Blot, flow cytometry, immunofluorescence, and ELISA are also a plus.

  • Bachelor’s degree in Biology or equivalent discipline with 6-8 years of experience in the Biotech/Pharma or a Masters in Biology or equivalent discipline, preferably with 5-6 years of experience in the Biotech/Pharma industry
  • Experience in handling, dosing and tissue harvesting from rodents is a requirement.
  • Hands-on experience performing in vivo studies, preferably with small molecule drug candidates, using multiple dose routes (IV, PO, SC, IM), tissue sample collection, and evaluating pharmacodynamic endpoints. 
  • Expertise in a variety of laboratory techniques such as sterile tissue culture techniques, developing and maintaining cell lines as well as biochemical techniques including, Western Blot, real time PCR, flow cytometry, immunofluorescence, and ELISA
  • Expertise with in vitro immunology assays: isolation and characterization of immune cells from human blood and mouse tissue, ideally T cell experience, set up of functional assays like mixed lymphocyte reactions, measurement of T cell proliferation
  • Detail oriented and with good time management skills
  • Must be proactive, co-operative, and willing to work in a small team environment
  • Excellent verbal and written communication skills
  • Proficient with MS Office and other commonly used software

Inception Sciences offers competitive compensation and excellent benefits packages, as well as working in a supportive team environment. We invite you to consider a career with Inception by submitting your resume to HR@inceptionsci.com.


Senior Scientist – Medicinal Chemistry in San Diego

Inception Sciences, San Diego CA is looking for an enthusiastic, hard-working and highly motivated Medicinal Chemist to join our multidisciplinary drug discovery team in developing small molecule therapeutics to treat cancer, fibrosis and inflammation. The ideal candidate will have a strong synthetic chemistry background and a verifiable track-record in small molecule drug discovery with 5 to 7 years relevant experience.

Responsibilities will include, but are not limited to, the following:

  • Design and synthesis of SAR for chosen drug targets.
  • Data interpretation and presentation to both project teams and the company as a whole on a regular basis.
  • Supervision of an associate chemist and/or potential management of external chemistry resources.

Requirements

  • Organic Chemistry PhD with at least 5 years of experience in small molecule drug discovery.
  • Experience in analyzing SAR and triaging new target molecules.
  • Thorough understanding of the basic drug discovery precepts such as metabolism, pharmacokinetics, in-vitro/in-vivo assay workflows.
  • Proficiency in preparing data presentations for team and company-wide presentation.
  • Organized, self-motivated, able to multitask and deliver results with a high degree of attention to detail.
  • Excellent written and verbal communication skills.
  • A strong team player that enjoys drug discovery and making a meaningful impact to drive projects forward.

Inception Sciences offers competitive compensation and excellent benefits packages, as well as working in a supportive team environment. We invite you to consider a career with Inception by submitting your resume to HR@inceptionsci.com.


DMPK Research Scientist or Equivalent Position in San Diego

Inception Sciences in San Diego CA is looking for an enthusiastic, hard-working and highly motivated Research Scientist to join our multidisciplinary drug discovery team developing small molecule therapeutics to treat cancer, fibrosis and inflammation. The ideal candidate should have strong hands-on in vitro ADME and bio-analytical skills. The candidate should be able to design and perform in vitro ADME studies and be experienced in LC-MS/MS based analysis of drug content in a variety of biological matrices. Experience with solubility testing and cell based assays are preferred but not a must.

Responsibilities will include, but are not limited to, the following:

  • Bio-analysis supporting PK, toxicity, PD and efficacy studies. Analyze data using Phoenix software and report results to project teams.
  • Design and conduct in vitro ADME studies to help guide SAR and IND filings.
  • Participate on project teams to provide DMPK expertise and enable fast progression of programs. Help identify relevant studies and work within team to establish a work plan for DMPK support.
  • Collaborate with Biology and Chemistry groups and design and perform studies to meet project and company goals.
  • Train other associates and interns in the DMPK group in areas of expertise.
  • Strong laboratory notebook skills, a desire to optimize methods and attention to details are all critical.

Requirements

  • BS degree with 10 years industry experience or MS degree with 5 years of hands-on bio-analysis and in vitro ADME laboratory experience in a relevant industry. Background in small molecule drug discovery is highly preferred.
  • Experience in LC-MS/MS based analysis of small molecules is a requirement.
  • Knowledge of common MS based software, ability to trouble shoot and maintain Sciex instruments.
  • Hands-on experience performing in vitro studies: CYP inhibition, plasma protein binding, solubility testing, PAMPA etc.
  • Experience with cell based assays desired but not a must.
  • Competency to optimize procedures and use robotics to enable fast turn-around of data.
  • Organized, self-motivated, able to multitask and deliver results with high degree of attention to detail.
  • Excellent written and verbal communication skills.
  • A strong team player that enjoys drug discovery and impacting programs by providing appropriate and fast DMPK support to drive projects forward.

Inception Sciences offers competitive compensation and excellent benefits packages, as well as working in a supportive team environment. We invite you to consider a career with Inception by submitting your resume to HR@inceptionsci.com.